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|Title: ||A STUDY ON EFFECTS OF COMBINATION THERAPY OF METFORMIN GLIMEPIRIDE AND TENELIGLIPTIN ON INSULIN RESISTANCE LIPID PROFILE RENAL PROFILE AND HEPATIC PROFILE IN NORTH INDIAN TYPE II DIABETIC POPULATION|
|Keywords: ||Metformin, Glimepiride, Teneligliptin, Insulin Resistance, HOMA-and#946;, HOMA- IR, QUICKI.|
|Researcher: ||M.RAJESH KUMAR|
|Guide(s): ||DR. BIJAY KUMAR|
|Registration Date: ||22.03.2016|
|Abstract: ||A study on effects of combination therapy of Metformin, Glimepiride andTeneligliptin on Insulin Resistance, Lipid profile,Renal profile and Hepatic Profile in NorthIndian type-II Diabetic population.
newlineIntroduction: Type-2 diabetes is a metabolic disease that affects millions of people worldwide which is characterized by elevated fasting plasma glucose, insulin resistance, unusually elevated hepatic glucose production, and reduced glucose-stimulated insulin secretion. Insulin resistance and impaired insulin secretion are the main patho-physiological defects responsible for the development of hyperglycemia in type 2 diabetes. Hypothesis: 1) Combination therapy of Metformin, Glimepiride and Teneligliptin may produce significant beneficial effects, play a role in decreasing insulin resistance and improves beta cell function and variations that occur in blood glucose, lipid profile, renal profile and hepatic profile may establish the advantage of combination therapy and helps as a biomarker for reporting adverse drug effects that may occur during therapy. Aim: The aim is to study the effects of combination therapy of Metformin, Glimepiride and Teneligliptin and their effect on insulin resistance, lipid, renal and hepatic profile in north Indian type-II diabetic population. Objectives: - 1. To study effects that occur mainly in insulin resistance, Lipid profile, Fasting blood glucose, renal profile and hepatic profile with the combination of drugs, 2) Effects of combination therapy and its influence on Insulin resistance.3) Establish the safety, efficacy and to report any adverse effects associated in management of type-2 diabetes 4) To find out most suitable drug regimen for our diabetic patients in Eastern UP. Materials and Methods: Study will be conducted in the Department of pharmacology with the collaboration of General Medicine and Biochemistry in Rama Medical College, Hospital and Research Institute, Kanpur, U. P. Study Design: A Non Randomized prospective Clinical Trial, Sample size:|
|Appears in Department:||Department of Pharmacology|
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