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Title: Synthesis and evaluation of novel polymeric prodrugs for the treatment of colon cancer
Keywords: Novel polymeric prodrugs
Treatment of colon cancer
Researcher: Sandeep Kumar
Guide(s): Bhardwaj, T R
Registration Date: 2018
Abstract: There are adequate anticancer drugs which are being used clinically, but these are highly toxic, not only to cancerous cells but normal cells also. Thus these anticancer drugs are neither site specific nor free from adverse toxic effects. Taking into consideration dire need to have site specific drug delivery to the cancerous colon, therefore, it was considered of interest to design and synthesize polyphosphazene and inulin linked prodrugs for colorectal cancer to have the targeted delivery of anticancer drugs to the colon only. In this approach, the anticancer drugs will be linked with biodegradable polymers such as polyphosphazene and inulin through azo linkage to have targeted delivery to the colon. The enzyme azo reductase present in the colon will act upon the polymer-linked prodrug and release the anticancer drug at the colon only. In addition, the conjugated biodegradable polymers have also been proved to increase drug stability. This approach will not only deliver the anticancer drug at the colon but also improve therapeutic index and expected to be devoid of toxicity. The proposed technical approach involves the synthesis of novel polymeric prodrugs of polyphosphazene and inulin linked clinically used anticancer drugs to have the desired targeted delivery of the anticancer drugs to the cancerous colon.
Language: English
Appears in Department:School of Pharmacy and Emerging Sciences

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